Faculdade da Farmácia, U.Porto
R. de Jorge Viterbo Ferreira 228
Building 3, 5th floor
Porto, Portugal


Ongoing Projects

SafeFood: Development of a novel industrial process for safe, sustainable and higher quality foods, using biotechnology and cybernetic approach

ERA-IB-16-014, Carla Novais (Collaborator), Patricia Antunes (Collaborator), Luisa Peixe (National PI).

Diabetes, Drug Abuse and Kidney Diseases (DESignBIOtecHealth)

NORTE-01-0145-FEDER-000024, Ana R. Freitas (Collaborator), Liliana Silva (Collaborator), Luisa Peixe, (Collaborator), Pedro Fernandes/Félix Carvalho/Alice Silva (PI).

Qualidade e Segurança Alimentar – uma abordagem (nano)tecnológica

NORTE-01-0145-FEDER-000011, Carla Novais (Collaborator), Patricia Antunes (Collaborator), Joana Mourão (Collaborator), Luisa Peixe (Collaborator), Isabel Ferreira (PI).

Discrimination of Salmonella non-typhoid high-risk clones by highthroughput spectroscopic techniques (MALDI-TOF and FTIR-ATR)

European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group Research Grant conceded by the ESCMID Executive Committee, Patricia Antunes (Collaborator), Carla Novais (Collaborator), Joana Campos (Collaborator), Clara Sousa (Collaborator), Luisa Peixe (PI).

Research Highlights

  • Enhanced tolerance to biocides (e.g. benzalkonium chloride, silver or copper) in antibiotic resistant Salmonella 4,[5],12:i:- and/or E. faecium clones, were associated with the acquisition of particular genes (qacZ/sil/pcoD). Moreover, we identified mcr-1, a recently recognized gene conferring resistance to colistin, a last resort antibiotic in Salmonella isolates with acquired tolerance to copper.
  • An importation to Europe of a plasmidic gene (FosA3) conferring resistance to fosfomycin was described, amplifying the resistance genes of concern in our area.
  • Development of a carbapenemase detection test with proving marketable applications.
  • qnrB genes, conferring resistance to quinolones, are intrinsic of Citrobacter spp., with particular species acting as source of the ones circulating in Enterobacteriaceae plasmids. Towards the recognition of Citrobacter species of higher human risk?
  • Recognition of new settings (e.g. ready-to-eat street food) or locations (Angola) as reservoirs of resistance genes or clinically relevant bacteria
  • We alert for the possibility of co-infection with different MDR E. faecium strains that could be missed in the diagnostic, potentiating therapeutic failures and poor outcomes.
  • Identification of a reliable biomarker for species assignment within Citrobacter genus, with the description of Citrobacter europaeus, sp. nov. from water and human faecal samples.
  • Bacterial discrimination at clonal level within clinically relevant species by quick and unexpensive methods: Acinetobacter baumannii and Klebsiella pneumoniae clones identification by FTIR-ATR; Enterococcus faecium major clones identification by MALDI-TOF MS
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Photo of the team